1-(4-Fluorophenyl-1,2-dihydro-2-oxo-3-pyridinecarboxylic acid
3-Pyridinecarboxylic acid, 1-(4-fluorophenyl)-1,2-dihydro-2-oxo-
CAS: 868171-67-9
Molecular Formula: C12H8FNO3
1-(4-Fluorophenyl-1,2-dihydro-2-oxo-3-pyridinecarboxylic acid - Names and Identifiers
1-(4-Fluorophenyl-1,2-dihydro-2-oxo-3-pyridinecarboxylic acid - Physico-chemical Properties
| Molecular Formula | C12H8FNO3 |
| Molar Mass | 233.2 |
| Density | 1.464±0.06 g/cm3(Predicted) |
| Melting Point | 213-215 °C |
| Boling Point | 429.6±45.0 °C(Predicted) |
| pKa | 2.07±0.20(Predicted) |
| Storage Condition | 2-8℃ |
1-(4-Fluorophenyl-1,2-dihydro-2-oxo-3-pyridinecarboxylic acid - Introduction
3-Pyridinecarboxylic acid, 1-(4-fluorophenyl)-1,2-dihydro-2-oxo-is also known as 3-pyridinecarboxylic acid, 1-(4-fluorophenyl)-1,2-dihydro-2-one. The following is a detailed description of the properties, uses, preparation and safety information of the compound:
Nature:
3-Pyridinecarboxylic acid, 1-(4-fluorophenyl)-1,2-dihydro-2-oxo-is a white crystalline solid. It is stable at room temperature, but insoluble in water. It is soluble in organic solvents such as ethanol and dimethylformamide.
Use:
The compound is an intermediate in organic synthesis. It has certain applications in the field of pesticides and pharmaceuticals, and is commonly used in the preparation of various pharmaceutically active monomers and compounds. In addition, it can also be used as a raw material for dye synthesis.
Preparation Method:
3-Pyridinecarboxylic acid, 1-(4-fluorophenyl)-1,2-dihydro-2-oxo-can be prepared by the following steps:
First, 1-(4-fluorophenyl)-2-bromoethanone and pyridine are subjected to a transesterification reaction to obtain methyl 1-(4-fluorophenyl)-1,2-dihydro-2-carbonyl-3-pyridinecarboxylate. Then, the desired 3-Pyridinecarboxylic acid, 1-(4-fluorophenyl)-1,2-dihydro-2-oxo-is prepared by converting the methyl ester group to a carboxylic acid group by a hydrolysis reaction-.
Safety Information:
There are no specific health and safety warnings regarding the safety of 3-Pyridinecarboxylic acid, 1-(4-fluorophenyl)-1,2-dihydro-2-oxo. However, as a chemical substance, although it is stable at room temperature, it is still necessary to avoid inhaling its powder or solution during use. At the same time, it is also necessary to avoid contact with strong oxidants and strong acids to avoid reactions. During use and storage, please follow the relevant laboratory safety procedures. If you have any questions or discomfort, please consult a professional in time.
Nature:
3-Pyridinecarboxylic acid, 1-(4-fluorophenyl)-1,2-dihydro-2-oxo-is a white crystalline solid. It is stable at room temperature, but insoluble in water. It is soluble in organic solvents such as ethanol and dimethylformamide.
Use:
The compound is an intermediate in organic synthesis. It has certain applications in the field of pesticides and pharmaceuticals, and is commonly used in the preparation of various pharmaceutically active monomers and compounds. In addition, it can also be used as a raw material for dye synthesis.
Preparation Method:
3-Pyridinecarboxylic acid, 1-(4-fluorophenyl)-1,2-dihydro-2-oxo-can be prepared by the following steps:
First, 1-(4-fluorophenyl)-2-bromoethanone and pyridine are subjected to a transesterification reaction to obtain methyl 1-(4-fluorophenyl)-1,2-dihydro-2-carbonyl-3-pyridinecarboxylate. Then, the desired 3-Pyridinecarboxylic acid, 1-(4-fluorophenyl)-1,2-dihydro-2-oxo-is prepared by converting the methyl ester group to a carboxylic acid group by a hydrolysis reaction-.
Safety Information:
There are no specific health and safety warnings regarding the safety of 3-Pyridinecarboxylic acid, 1-(4-fluorophenyl)-1,2-dihydro-2-oxo. However, as a chemical substance, although it is stable at room temperature, it is still necessary to avoid inhaling its powder or solution during use. At the same time, it is also necessary to avoid contact with strong oxidants and strong acids to avoid reactions. During use and storage, please follow the relevant laboratory safety procedures. If you have any questions or discomfort, please consult a professional in time.
Last Update：2024-04-09 21:54:55
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CAS: 868171-67-9
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CAS: 868171-67-9
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